Gene Ontology Help

Calcineurin complex variant 1 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

A Ca2+/calmodulin-regulated Ser/Thr protein phosphatase, highly conserved through evolution and a critical component of Ca2+-regulated signaling in a wide range of unicellular and multicellular eukaryotes. Calcineurin is a heterodimer containing a catalytic (A) subunit complexed with an essential regulatory (B) subunit. Calcineurin function requires interaction of both subunits. The catalytic subunit contains an active site dinuclear metal center. The regulatory subunit is tightly associated, myristoylated and binds Ca2+ via four Ca2+-binding EF-hand motifs. Two redundant genes, CNA1 and CNA2, encode the catalytic subunit and their expression is regulated in a cell cycle-dependent manner. In the yeast, Ca2+ signaling mediated by calcineurin, is required for survival during environmental stress. One role of the phosphatase under these conditions is to activate gene expression through its regulation of the CRZ1 (P53968) transcription factor. Calcineurin controls many other physiological processes in yeast, including cell cycle progression, cation homeostasis, morphogenesis, establishment of cell polarity and regulation of cell wall biosynthesis. Cells deficient for calcineurin are unable to survive pheromone-induced G1 arrest. When mobilization of internal calcium stores occurs, the catalytic subunit is bound by Ca2+-calmodulin and the active site is freed by displacement of the autoinhibitory domain.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

hydrolase activity, ion binding, phosphatase activity, homeostatic process, intracellular monoatomic ion homeostasis