Gene Ontology Help

PMT5-PMT3 dolichyl-phosphate-mannose-protein mannosyltransferase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Initiates protein O-mannosylation by catalyzing the transfer of a mannosyl residue from dolichol-phosphate-beta-D-Mannose to Ser and Thr residues of proteins in an alpha-D-mannosidic linkage. Some proteins with moderate Ser/Thr content are O-mannosylated when they are not properly folded. In the endoplasmic reticulum this removes them from folding cycles by reducing engagement with the KAR2 chaperone (P164740). O-mannosyl glycans are important for the stability, localization and/or function of various secretory and membrane proteins and hence cell wall integrity. Acts on both soluble and membrane proteins.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

glycosyltransferase activity, transferase activity, cell wall organization or biogenesis, protein glycosylation, cellular component