Gene Ontology Help

Nucleolar ribonuclease MRP complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Site-specific endonuclease, closely related to RNAse P complex (CPX-1873). Most protein subunits are common between the two complexes, only SNM1 and RNP1 are unique to MRP, as well as the RNA component NME1. RNAse MRP is involved in rRNA processing in the nucleolus, but during exit from mitosis it also localizes to specialized cytoplasmic P bodies and participates in cleaving CLB2 mRNA. The RNA subunit NME1 is a catalytically active ribozyme that is capable of both recognizing and cleaving substrates, Despite its name (Mitochondrial RNA Processing) the nucleolar complex is not involved in processing mitochondrial RNA.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, hydrolase activity, nuclease activity, cellular nitrogen compound metabolic process, rRNA processing, ribonuclease MRP complex, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex