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SUMO activating enzyme complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
SUMO activating complex provides an E1-like activity that catalyzes the first step in conjugation of Smt3 (SUMO) to proteins (sumoylation). The activated Smt3 is then transferred to the E2-like SUMO conjugating enzyme Ubc9. In subsequent steps, Smt3 is covalently attached to lysine residues on target proteins by one of the E3-like SUMO ligases that include Siz1, Mms21, Cst9, and Nfi1. Attachment of Smt3 alters protein-protein and protein-DNA interactions, as well as subcellular localization of the target proteins, among which are septins, several DNA repair proteins, and cell division regulators, therefore affecting chromosome segregation, cell cycle control, and likely many other regulatory pathways.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ligase activity, peptidyl-amino acid modification, protein modification by small protein conjugation or removal, SUMO activating enzyme complex