Gene Ontology Help

SCF-Dia2 ubiquitin ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

SCF-Dia2 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, Dia2, forms the substrate recognition subunit. The complex may form a homodimer. SCF-Dia2 is involved in a number of cellular processes: it has been associated with replication stress response and is considered part of the replisome progression complex responsible for fork stability. CSF-Dia2 has also been linked to part of the intra-S phase DNA damage checkpoint. It is also involved in transcriptional silencing at telomeres and mating type loci, as well as regulating transcription by mediating assembly of the RSC complex. It is required for the degradation of Cdc6 in G1.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, DNA damage response, catabolic process, chromatin organization, proteolysis involved in protein catabolic process, regulation of cell cycle, response to stress, signal transduction