Gene Ontology Help

SCF-MET30 E3 ubiquitin ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
SCF-Met30 is a member of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase family, in which the F-box protein, MET30, forms the substrate recognition subunit. The complex is required for the ubiquitylation of the transcription factor MET4 (P32389), resulting in its deactivation, and destabilization of the cell cycle inhibitor MET32 (Q12041), thus enabling cell cycle progression. MET4 is the master regulator of genes governing the synthesis of sulfur-containing amino acids, therefore SCF-MET30 coordinates cell cycle progression with biosynthetic pathways of sulfur-containing metabolites, such as methionine, cysteine, and S-adenosylmethionine. The complex may form a homodimer.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, catabolic process, proteolysis involved in protein catabolic process, regulation of cell cycle