Gene Ontology Help

SEA complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Vacuole associated growth regulator that acts as a GTPase-activating protein (GAP) for GTR1 (Q00582), a Rag GTPase that relays nutrient status to the Target of Rapamycin Complex 1 (CPX-1715, CPX-1716) One end of the SEA complex is made of the IML1/NPR2/NPR3 trimer (SEACIT), involved in inhibition of TORC1 signaling, while the other end, composed of RTC1/MTC5/SEA4/SEH1/SecEC13 (SEACAT), is involved in the activation of TORC1 signaling by acting as a scaffold for the binding of TORC1 regulators. The complex thus regulates TORC1 signaling and is involved in maintaining vacuolar integrity, regulating autophagy in response to nitrogen starvation. A putative GEF activity was suggested for NPR2 and NPR3.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

biological process, membrane