Gene Ontology Help

MIS complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
The MIS complex is a methyltransferase which methylates adenosine at the N6 position to form N6-methyladenosine. mRNA methylation in Saccharomyces cerevisiae occurs only during meiosis. During meiosis, complete mRNA methylation requires MIS complex localization to the nucleolus in a Slz1-dependent manner. NDT80 also regulates Mum2 and Ime4 nucleolar localization during meiosis. Methylation of mRNA by this complex suppresses pseudohyphal development.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

methyltransferase activity, transferase activity, RNA modification, cellular nitrogen compound metabolic process