Gene Ontology Help

Mitochondrial pyruvate dehydrogenase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Mitochondrial matrix enzyme that converts pyruvate to acetyl-CoA and CO2. This provides a metabolic connection between glycolysis, whose end product is pyruvate, and the tricarboxylic acid cycle, which starts with acetyl-CoA. Pyruvate dehydrogenase (PDH) activity is negatively regulated via phosphorylation of its PDA1 subunit. The protein kinases PKP1 (P40530) and PKP2 (P53170) phosphorylate PDA1, and the protein phosphatases PTC5 (Q12511) and PTC6 (P25646) mediate its dephosphorylation.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, ion binding, oxidoreductase activity, transferase activity, biosynthetic process, cellular nitrogen compound metabolic process, monocarboxylic acid metabolic process, nucleobase-containing small molecule metabolic process, small molecule metabolic process, sulfur compound metabolic process, mitochondrion, organelle