Gene Ontology Help

EGO complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

The EGO complex is localized to the vacuolar membranes and activates vacuolar membrane associated TORC1 in the presence of preferred nitrogen sources. It thereby has an important role in regulating cell growth and autophagy by relaying amino acid signals. Specifically, its subunit GTR1 becomes activated to a GTP-bound form in a downstream response to nutrient signals, causing EGO to interact with and activate TORC1. EGO is required for recovery from rapamycin-induced growth arrest and positively regulates microautophagy.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

GTPase activity, hydrolase activity, ion binding, catabolic process, membrane