Gene Ontology Help

Telomerase holoenzyme complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Telomerase is a ribonucleoprotein complex that is essential for maintenance of telomeres. It is a reverse transcriptase that elongates the single-stranded G-rich 3' protruding ends of chromosomal DNA using TLC1 RNA as a template. Est1 and TLC1 are sufficient for telomerase activity in vitro, but in vivo all 4 subunits are required. Although telomerase activity can be detected throughout the cell cycle, telomeres are only elongated in late S-phase. Telomerase is known to interact with other complexes, including CDC13 complex (via EST1), Yku70/80 complex (CPX-1732) (via TLC1) and Sm heteroheptameric complex (via TLC1).
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, nucleotidyltransferase activity, transferase activity, DNA metabolic process, biosynthetic process, chromosome organization, telomere organization