Gene Ontology Help

CBF3 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Binds to the CDEIII DNA element, conserved between all yeast chromosomes, early in kinetochore assembly and acts as the the primary determinant of assembly. Binding of the CBF3 complex and presence of the unique N-terminal tails of the two CSE4 (P36012) molecules in the nucleosome could cooperate to induce a sharp bending of the centromeric DNA, thus creating a C-loop structure in which the CSE4 nucleosome is proximal to the plus end of the kinetochore. Alternatively, CSE4-nucleosomes are part of the highly phased array of nucleosomes on either side of the CEN-sequence, while CFB3 occupies CDEIII and additional Ndc10 molecules occupy the CDEII sites to form an extended binding platform. microtubule
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, cellular component assembly, chromosome organization, organelle assembly, protein-containing complex assembly, organelle, CBF3 complex, kinetochore