Gene Ontology Help

Nucleolar ribonuclease P complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Responsible for the 5' endonucleolytic cleavage of precursor tRNAs (pre-tRNAs), catalyzing phosphodiester bond hydrolysis to remove approximately 12 leader nucleotides to yield mature tRNAs. The RNA subunit of the nucleolar RNase P is a catalytically active ribozyme that is capable of both recognizing and cleaving substrates efficiently and accurately. The protein component serves as an absolutely required cofactor.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, hydrolase activity, nuclease activity, cellular nitrogen compound metabolic process, tRNA metabolic process, tRNA processing, nucleolar ribonuclease P complex, ribonuclease P complex, ribonucleoprotein complex