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Myosin class V complex, MYO4 variant Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Building block of the class V myosin processive molecular motor involved in a range of organelle-transporting functions, including the transport of vacuoles and mRNA. The myosin heavy chain motor domain mediates the ATP-dependent interaction with the F-actin cytoskeleton. The myosin neck region with the bound light chains acts as a rigid lever arm that amplifies movements within the myosin motor domain into a large mechanical stroke that directionally propels the myosin along the actin filament. Myosin V has a high duty cycle, i.e. remains attached to actin for a large fraction of the mechanochemical cycle due to the slow rate of ADP release, the rate-limiting step in the ATPase cycle. This kinetic adaptation allows myosin V to take multiple steps without dissociating from the actin filament. Myosin V can take large steps of approximately 36nm, a distance equal to the helical repeat of the actin filament allowing Myosin V to walk in a straight line on the actin filament, in a hand-over-hand fashion.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, cytoskeletal protein binding, hydrolase activity, ion binding, cytoskeleton-dependent intracellular transport, transport, myosin V complex