Gene Ontology Help

UBP3-BRE5 ubiquitin hydrolase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Specifically deubiquitylates and consequently controls the expression level of the SEC23 (P15303) and SEC27 (P41811) subunits of the COPII (CPX-2523) and COPI complexes that regulate anterograde and retrograde transport between the endoplasmic reticulum and the Golgi apparatus respectively. Also required for the assmbly of nonmembranous ribonucleoprotein stress granules. Inhibits mitophagy but promotes other types of autophagy, including ribophagy. The complex translocates dynamically from the cytosol to the mitochondria upon induction of mitophagy.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

hydrolase activity, peptidase activity, catabolic process, cellular component assembly, organelle assembly, regulation of organelle organization, regulation of transport, cytosol, mitochondrion, organelle