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Synaptonemal complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Liquid crystalline structure that assembles between homologous chromosomes during meiotic prophase. Required for stabilising chromosome pairing and alignment, and for crossover events and chiasmata formation between homologous chromosome pairs. Mediates the lengthwise alignment of homologous chromsomes within 100 nm of each other witht hread-like axial or lateral elements are paired together by transverse filaments formed by oligomerized ZIP1 proteins. The axial element contains the axis proteins RED1 and HOP1 which appear to require the activity of the meiotic cohesin complex (CPX-1408) for correct assembly. ZIP1 dimers are organized near their N-termini by a complex of proteins including ECM11 and SUMOylated ECM11. ECM11 SUMOylation promotes ZIP1 assembly whilst ZIP1 promotes ECM11 SUMOylation in a positive feedback loop leading to further assembly of ZIP1, loading of ECM11/GMC2 and SUMOylation of ECM11 until the Synaptonemal complex is fully established.