Complex: NVJ1-VAC8 nucleus-vacuole junction complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1381
- Systematic Name
- NVJ1:VAC8
- SGD ID
- SGD:S000217727
- Aliases
- nucleus-vacuole junction
- Description
- Nucleus-vacuole junction complex, a membrane contact site formed between perinuclear and vacuolar membranes. Mediates essential cellular processes such as piecemeal microautophagy of the nucleus (PMN), a selective autophagic recycling process stimulated by carbon or nitrogen starvation through the target of rapamycin signaling pathway. Under these conditions, the region of the nucleus in the vicinity of NVJs invaginates into the vacuolar lumen and forms a bleb-like structure, which is released as a vesicle and eventually degraded by vacuolar hydrolases. NVJs are also involved in lipid metabolism by recruiting the two lipid-modifying enzymes, oxystereol-binding proteins homology OSH1 (P35845) involved in nonvesicular lipid trafficking and the enoyl-CoA reductase TSC13 (Q99190) that mediates the synthesis of very-long-chain fatty acids.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 5XJG |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Biological Process
-
- involved in lipid metabolic process (BSR)
- involved in piecemeal microautophagy of the nucleus (BSR)
- Cellular Component
-
- located in integral component of nuclear outer membrane (BSR)
- located in nuclear outer membrane (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
No shared annotations
Resources
IntAct | ModelArchive | PDB:5XJG ... Show all Show fewer