Gene Ontology Help

SMC5-SMC6 SUMO ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

SUMO ligase complex with a role in homologous recombination (HR) and replication. Required for chromosome segregation at repetitive sequences. Localizes to repetitive elements such as the rDNA and telomeres where is is thought to promote and resolve HR-dependent intermediates using ATP-hydrolysis to symmetrically reel DNA into loops. Also required for telomere maintenance during replication and telomere elongation and for SUMOylating components of the replisome, such as MCM2 (P29469) and the POL2 (P21951) subunit of the DNA polymerase epsilon complex (CPX-2110), which is important for replication fork progression in the presence of DNA-damaging agents.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, acyltransferase activity, transferase activity, DNA damage response, DNA metabolic process, DNA recombination, DNA repair, cellular nitrogen compound metabolic process, chromatin organization, peptidyl-amino acid modification, protein modification by small protein conjugation or removal, regulation of DNA metabolic process, regulation of organelle organization, response to stress, cellular component