Gene Ontology Help

RVS161-RVS167 amphiphysin complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Binds to membranes and promote the membrane curvature required for endocytosis and also potentially membrane scission at the sites of endocytosis. The BAR domains present in both proteins form helical structures at the neck of the invaginating plasma membrane. Functions with INP52 (P50942) to promote scission of the vesicle. The complex appears to protect the PI(4,5)P2 in the vesicle neck resulting in differential hydrolysis by INP52 to generate a lipid phase boundary. This leads to a mechanochemical interfacial force, driving membrane scission. In growing yeast cells, the complexes localize to cortical actin patches, which are sites of endocytosis.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

cytoskeletal protein binding, cellular component assembly, membrane organization, plasma membrane organization, protein-containing complex assembly, regulation of transport, cellular component