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Snf1 protein kinase complex variant SIP1 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Energy sensor protein kinase complex, activated by glucose depletion. Regulates cellular energy metabolism by activating energy-producing pathways and inhibiting energy-consuming processes via derepression of glucose-repressed genes. Required for the diauxic shift, in which genes required for mitochondrial oxidative metabolism (normally repressed by glucose) are switched on; growth then resumes at a lower rate. The activity of this complex is modulated by reversible phosphorylation of SNF1 Thr-210 which increases in response to glucose starvation and correlates with large increases in cellular ADP-to-ATP and AMP-to-ATP ratios. Binding of ADP, but not AMP, to the complex protects against dephosphorylation of Thr-210, suggesting that ADP, rather than AMP, may be the critical activating signal. When glucose levels are high, the complex is cytoplasmic. Upon glucose depletion, SIP1-containing SNF1 locates to the vacuolar membrane.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ion binding, kinase activity, transferase activity, biological process, nucleotide-activated protein kinase complex