Gene Ontology Help

Mitochondrial NIAUFX iron-sulfur cluster assembly complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Required for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. NFS1 provides sulfur for Fe-S cluster assembly by cleaving this atom from the side chain of the substrate L-cysteine and storing it in the form of a persulfide. The ISU1 scaffold protein performs the transient assembly of the 2Fe-2S cluster using persulfide sulfur and Fe(II). Electrons are provided by a mitochondrial ferredoxin, YAH1.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

oxidoreductase activity, transferase activity, cellular component assembly, mitochondrion, organelle