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Complex: GID E3 ubiquitin ligase complex, GID4 variant

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
SGD
ComplexAc
CPX-301
Systematic Name
FYV10:GID7:GID8:RMD5:VID24:VID28:VID30
SGD ID
SGD:S000217674
Aliases
FBP degradation complex
Description
E3 ubiquitin ligase complex that triggers polyubiquitylation and subsequent proteasomal degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase (P09201), phosphoenolpyruvate carboxykinase (P10963) and cytoplasmic malate dehydrogenase (P22133). The complex functions as the N-recognin of the GID-mediated proteolytic system termed the Pro/N-degron pathway and targets proteins by recognizing their N-terminal Pro residues or a Pro at position 2.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

6SWY 6SWY 7NS4 7NS4 7NSB 7NSB

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

EMDB: EMD-10333 | EMDB: EMD-12541 | EMDB: EMD-12548 | EMDB: EMD-12560 | EMDB: EMD-12563 | IntEnz: 2.3.2.27

Resources

IntAct | ModelArchive | PDB:6SWY | PDB:7NS4 | PDB:7NSB