Gene Ontology Help

Nucleosome, variant HTZ1-HTB2 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. The H2A.Z nucleosome acts as a barrier that occludes the transcription start sites at the edge of the nucleosome-free region, potentially keeping promoters in a repressed state. The complex additionally helps position downstream nucleosomes in the coding region. SWR1 (CPX-2122) replaces the canonical H2A/H2B dimer at nucleosomes flanking histone-depleted regions, such as promoters, with the variant histone H2A.Z/H2B dimer.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

chromatin organization, nucleus, organelle