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Importin complex, KAP60-KAP95 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
A nuclear import complex that functions as a nuclear import receptor for proteins containing a nuclear localisation signal (NLS). Subunit SRP1 specifically and directly binds to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KAP95. KAP95 binds to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, GSP1-dependent mechanism. At the nucleoplasmic side of the NPC, GSP1-GTP (P32835) binds to KAP95, the three components separate and SRP1 and KAP95 are re-exported from the nucleus to the cytoplasm where GTP is hydrolysed. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of GSP1 between the cytoplasm and nucleus.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

molecular function, nuclear transport, nucleocytoplasmic transport, transport, cytosol, nuclear envelope