Complex: BUD23-TRM112 methyltransferase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1047
- Systematic Name
- BUD23:TRM112
- SGD ID
- SGD:S000217653
- Aliases
- S-adenosyl-L-methionine-dependent methyltransferase complex ; S-adenosylmethionine-dependent methyltransferase complex ; SAM-dependent methyltransferase complex
- Description
- S-adenosylmethionine-dependent methyltransferase which plays a role in the synthesis of the small ribosomal subunit by catalyzing the N7-methylation of guanosine-1575 of 18S rRNA at the 20S pre-rRNA stage. The complex interacts with the box C/D snoRNA U3-associated DEAH RNA helicase DHR1, which appears to play a role in central pseudoknot formation, so may also contribute to controlling the folding of small subunit rRNA. May play a role in 40S ribosome maturation.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables S-adenosyl-L-methionine binding (IPI)
- enables S-adenosylmethionine-dependent methyltransferase activity (BSR)
- enables preribosome binding (IPI)
- enables rRNA (guanine-N7-)-methyltransferase activity (BSR)
- Biological Process
-
- involved in rRNA (guanine-N7)-methylation (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Bourgeois G, et al. (2017) Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus. Biomolecules 7(1) PMID: 28134793
Resources
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