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MET4-MET28-MET32 sulfur metabolism transcription factor complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Transcription factor complex regulating sulfur metabolism. MET4 lacks DNA-binding ability and relies on interactions with MET31 (Q03081) and MET32, paralogous proteins that bind the same cis-regulatory element, to activate its targets. MET31 and MET32 are C2H2 zinc finger-containing proteins that act solely as adaptors for recruiting MET4 to promoters, binding to sites with a TGTGGC core. MET28 acts to stabilise the complex.