Gene Ontology Help

CUL8-MMS1-MMS22-ESC4 E3 ubiquitin ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Ubiquitin ligase complex required for the ubiquition of acetylated histone H3, thus facilitating nucleosome assembly during replication and promoting replication progression during S-phase. RTT107 may recruit and help load the complex onto a DNA damage site at or near a stalled replication fork.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, acyltransferase activity, transferase activity, cellular component assembly, chromatin organization, protein-containing complex assembly