Gene Ontology Help

Central kinetochore CTF19 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Present in the central kinetochore, where is appears to play a role in the enhancement of cohesin in the pericentromere. May help to mediate the attachment of the centromere to the mitotic spindle by forming interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. The COMA subcomplex proteins (CPX-1187) bind to the inner kinetochore proteins whilst the more peripheral proteins do not. Several of the subunits (IML3, CHL4, CTF19, MCM21, CTF3, MCM16 and MCM22) appear to be non-essential although their absence has a significant role in chromosome segregation in meiosis and more limited effects during mitosis. MTW1 is only present in low levels so may only associate with the complex.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

biological process, organelle, kinetochore