Gene Ontology Help

Cytoplasmic exosome complex, DIS3 variant Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
3-prime to 5-prime exo- and endoribonuclease complex that is involved in RNA maturation and degradation which include the removal of unstable and aberrant transcripts and may also regulate the levels of specific transcripts in response to environmental factors. Restricted to processing linear and circular single-stranded RNAs only. RNAs with complex secondary structures, particularly at the 3-prime end of the molecule, may have to be unwound or pre-processed by co-factors prior to entering the complex. Although some RNAs may be targeted directly to the catalytic subunit, the majority of substrates enter the barrel-like structure of the exosome through a pore at the centre of the cap and are threaded through the central channel in a 3-prime to 5-prime orientation. The ribonuclease activity of the catalytic subunit facilitates the degradation process. Two different exosomes exist in yeast, one found in the nucleus and nucleolus (CPX-599), the other form is lacking the RRP6 (Q12149) subunit and is found in the cytosol (this complex). The cytoplasmic RNA exosome is involved in general mRNA turnover (esp of Polymerase III transcripts) and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3-prime untranslated regions and cytoplasmic rRNAs that have undergone polyadenylation. Degrades mRNAs subject to RNA interference and is involved in the following mRNA decay pathways: mRNAs with premature termination codons (PTCs; the nonsense mediated decay (NMD) pathway), ones lacking termination codons altogether (the non-stop decay (NSD) pathway) and ones where ribosomes stall (the no-go decay (NGD) pathway). May be involved in degradation of histone mRNA.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, hydrolase activity, nuclease activity, RNA catabolic process, catabolic process, cellular nitrogen compound metabolic process, nucleobase-containing compound catabolic process, nucleolus, nucleus, organelle, intracellular non-membrane-bounded organelle