Gene Ontology Help

Adaptor complex AP-1R Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Plays a central role in clathrin-coated vesicle formation by coupling coat assembly and cargo collection. Binds short linear motifs on cargo proteins and incorporates them into the clathrin coat of forming vesicles. Mediates the bi-directional transfer of membrane proteins between the trans-Golgi network and the early endosome. Related complexes AP-1 (CPX-532) and AP-1R differ only in the mu chain and sort different cargoes: for example, only AP-1R binds Yfl034w (P43564), a predicted serine hydrolase that is required for APM2-dependent sorting processes and has a role in recruiting APM2 to membranes.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

molecular function, biological process