Complex: Nuclear/nucleolar exosome complex, DIS3-RRP6 variant
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- 3'-5'-exoribonuclease activity
- endoribonuclease activity, producing 5'-phosphomonoesters
- single-stranded RNA binding
- Biological Process
-
- RNA catabolic process
- RNA processing
- Cellular Component
-
- exosome (RNase complex)
- nucleolus
- nucleus
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Kilchert C, et al. (2016) The regulation and functions of the nuclear RNA exosome complex. Nat. Rev. Mol. Cell Biol. 17(4):227-39 PMID: 26726035
- Kowalinski E, et al. (2016) Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. Mol Cell 63(1):125-34 PMID: 27345150
- Chlebowski A, et al. (2013) RNA decay machines: the exosome. Biochim Biophys Acta 1829(6-7):552-60 PMID: 23352926
- Makino DL, et al. (2013) Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex. Nature 495(7439):70-5 PMID: 23376952
- Schneider C and Tollervey D (2013) Threading the barrel of the RNA exosome. Trends Biochem Sci 38(10):485-93 PMID: 23910895
- Schneider C, et al. (2009) The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome. Nucleic Acids Res 37(4):1127-40 PMID: 19129231
- Schneider C, et al. (2007) The exosome subunit Rrp44 plays a direct role in RNA substrate recognition. Mol Cell 27(2):324-31 PMID: 17643380
- Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 PMID: 17174896
- Allmang C, et al. (1999) The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev 13(16):2148-58 PMID: 10465791
- Shiomi T, et al. (1998) Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. J Biochem 123(5):883-90 PMID: 9562621