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    Complex: Nuclear/nucleolar exosome complex, DIS3-RRP6 variant

    Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.


    Curated by
    IntAct
    ComplexAc
    CPX-599
    Systematic Name
    DIS3:EXOSC1:EXOSC2:EXOSC3:EXOSC4:EXOSC5:EXOSC6:EXOSC7:EXOSC8:EXOSC9:RRP6
    Aliases
    Nuclear exosome complex, RRP44-RRP6 variant

    Complex Diagram

    This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.


    PDB Structure

    When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.


    2WP8 2WP8 4IFD 4IFD 4OO1 4OO1

    Subunits

    This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.


    Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

    Subunit Description Stoichiometry

    Gene Ontology

    Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.


      Molecular Function
    • 3'-5'-exoribonuclease activity
    • endoribonuclease activity, producing 5'-phosphomonoesters
    • single-stranded RNA binding
      Biological Process
    • RNA catabolic process
    • RNA processing
      Cellular Component
    • exosome (RNase complex)
    • nucleolus
    • nucleus

    Shared Annotations

    This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.


    References

    List of references used specifically to curate the information on this page.


    • Kilchert C, et al. (2016) The regulation and functions of the nuclear RNA exosome complex. Nat. Rev. Mol. Cell Biol. 17(4):227-39 PMID: 26726035
      • SGD Paper
      • DOI full text
      • PubMed
    • Chlebowski A, et al. (2013) RNA decay machines: the exosome. Biochim Biophys Acta 1829(6-7):552-60 PMID: 23352926
      • SGD Paper
      • DOI full text
      • PubMed
    • Makino DL, et al. (2013) Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex. Nature 495(7439):70-5 PMID: 23376952
      • SGD Paper
      • DOI full text
      • PubMed
    • Schneider C and Tollervey D (2013) Threading the barrel of the RNA exosome. Trends Biochem Sci 38(10):485-93 PMID: 23910895
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Schneider C, et al. (2009) The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome. Nucleic Acids Res 37(4):1127-40 PMID: 19129231
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Schneider C, et al. (2007) The exosome subunit Rrp44 plays a direct role in RNA substrate recognition. Mol Cell 27(2):324-31 PMID: 17643380
      • SGD Paper
      • DOI full text
      • PubMed
    • Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 PMID: 17174896
      • SGD Paper
      • DOI full text
      • PubMed
    • Allmang C, et al. (1999) The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev 13(16):2148-58 PMID: 10465791
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Shiomi T, et al. (1998) Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. J Biochem 123(5):883-90 PMID: 9562621
      • SGD Paper
      • DOI full text
      • PubMed

    External Identifiers


    IntEnz: 3.1.13 | IntEnz: 3.1.26
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