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    Complex: Eukaryotic translation initiation factor 2B complex

    Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.


    Curated by
    IntAct
    ComplexAc
    CPX-429
    Systematic Name
    2xGCD1:2xGCD2:2xGCD6:2xGCD7:2xGCN3
    Aliases
    IF-2B complex ; IF2B complex ; eIF-2B complex ; eIF2B complex

    Complex Diagram

    This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.


    Subunits

    This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.


    Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

    Subunit Description Stoichiometry

    Gene Ontology

    Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.


      Molecular Function
    • guanyl-nucleotide exchange factor activity
    • translation initiation factor activity
      Biological Process
    • positive regulation of GTPase activity
    • regulation of translational initiation
      Cellular Component
    • eukaryotic translation initiation factor 2B complex
    • guanyl-nucleotide exchange factor complex

    Shared Annotations

    This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.


    References

    List of references used specifically to curate the information on this page.


    • Gordiyenko Y, et al. (2014) eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core. Nat Commun 5:3902 PMID: 24852487
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Jennings MD, et al. (2013) eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation. Genes Dev 27(24):2696-707 PMID: 24352424
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • Cigan AM, et al. (1993) A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Proc Natl Acad Sci U S A 90(11):5350-4 PMID: 8506384
      • SGD Paper
      • DOI full text
      • PMC full text
      • PubMed
    • SGD
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