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Complex: [Cu-Zn] Superoxide dismutase complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-2896
Systematic Name
SOD1 dimer
SGD ID
SGD:S000218124
Aliases
Copper–zinc superoxide dismutase
Description
Catalyzes the breakdown of two superoxide molecules into dioxygen and hydrogen peroxide in two asymmetrical steps using an essential copper atom in the active site of the enzyme. Reduction of the oxidized Cu(II) form of the enzyme by superoxide, releasing dioxygen (reaction 1), alternates with oxidation of the reduced Cu(I) form by another superoxide anion and two protons, generating hydrogen peroxide (reaction 2). Protects the cell guard against free radical species produced during cellular metabolism. SOD1 acquires its copper by forming a heterodimer with the copper chaperone, CCS (CPX-2267), which also is responsible for formation of an intramolecular disulfide bond required to increase the enzymatic activity from approximately 10 % in disulfide-reduced SOD1 to 100 % in disulfide-oxidized SOD1. The copper chaperone, CCS1 (CPX-2895), both delivers the copper and oxidises the disulfide bond. There is also evidence of CCS-independent activation of SOD1.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

1B4L 1B4L 1B4T 1B4T 1F18 1F18 1F1A 1F1A 1F1D 1F1D 1F1G 1F1G 1JCV 1JCV 1YAZ 1YAZ 1YSO 1YSO 2JCW 2JCW

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

IntEnz: 1.15.1.1

Resources

IntAct | ModelArchive | PDB:1B4L | PDB:1B4T | PDB:1F18 | PDB:1F1A | PDB:1F1D | PDB:1F1G | PDB:1JCV | PDB:1YAZ | PDB:1YSO ... Show all