Complex: DNA polymerase zeta complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1091
- Systematic Name
- POL31:POL32:REV3:REV7
- SGD ID
- SGD:S000217658
- Description
- Low-fidelity non-essential DNA polymerase that is involved in translesion DNA synthesis. Required for the majority of spontaneous mutagenesis in wild-type yeast cells, as well as for mutagenesis associated with transcription, with double-strand break repair, and with defective DNA repair.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 6V8P |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables DNA-directed DNA polymerase activity (IDA)
- enables DNA-directed DNA polymerase activity (IDA)
- enables mismatched DNA binding (IDA)
- Biological Process
-
- involved in error-prone translesion synthesis (IDA)
- involved in error-prone translesion synthesis (IDA)
- Cellular Component
-
- located in mitochondrion (IDA)
- located in nucleus (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Malik R, et al. (2022) Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch. Nat Commun 13(1):1050 PMID: 35217661
- Malik R, et al. (2020) Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis. Nat Struct Mol Biol 27(10):913-924 PMID: 32807989
- Acharya N, et al. (2009) Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase delta. Proc Natl Acad Sci U S A 106(24):9631-6 PMID: 19487673
Resources
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