Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
12 entries for 2 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
---|---|---|---|---|---|---|---|
SPF1 | chemical compound accumulation: decreased | classical genetics | null Allele: spf1-Δ | S288C | lanosterol | Details: significant reduction in total lanosterol, resulting in an ~4-fold greater ergosterol-to-lanosterol ratio | Sørensen DM, et al. (2019) PMID:30785834 |
MGE1 | chemical compound accumulation: decreased | classical genetics | overexpression | S288C | lanosterol | Treatment: 20 μg fluconazole | Demuyser L, et al. (2017) PMID:28720726 |
CAB1 | chemical compound accumulation: decreased | classical genetics | reduction of function Allele: cab1-G351S G351S; enzyme catalysis reduced by >90% | Other | lanosterol | Media: minimal medium supplemented with 100 μm pantothenic acid Temperature: permissive temperature, 30 °C Details: significant reduction in the levels of lanosterol compared to wt | Chiu JE, et al. (2019) PMID:31409644 |
DAP1 | chemical compound accumulation: increased | classical genetics | null Allele: dap1-Δ | W303 | lanosterol | Craven RJ, et al. (2007) PMID:17954932 | |
YTA7 | chemical compound accumulation: increased | classical genetics | null Allele: yta7-Δ | S288C | lanosterol | Details: 2-fold increase relative to wildtype | Kuranda K, et al. (2009) PMID:19416104 |
PDR18 | chemical compound accumulation: increased | classical genetics | null Allele: pdr18-Δ | S288C | lanosterol | Details: 2-fold accumulation detected in plasma membrane | Cabrito TR, et al. (2011) PMID:21831043 |
BRL1 | chemical compound accumulation: increased | classical genetics | conditional Allele: brl1-1 | Other | lanosterol | Temperature: permissive temperature, 24 °C Details: similar results with brl1-2 | Lone MA, et al. (2015) PMID:26432634 |
ARV1 | chemical compound accumulation: increased | classical genetics | reduction of function Allele: arv1-ΔAhd N-terminal truncation; Arv1 homology domain deleted | W303 | lanosterol | Details: altered sterol composition with accumulation of lanosterol | Villasmil ML, et al. (2020) PMID:32678853 |
ARV1 | chemical compound accumulation: increased | classical genetics | reduction of function Allele: arv1-Ahd C-terminal truncation; contains the Arv1 homology domain | W303 | lanosterol | Details: altered sterol composition with accumulation of lanosterol | Villasmil ML, et al. (2020) PMID:32678853 |
ARV1 | chemical compound accumulation: increased | classical genetics | reduction of function Allele: arv1-C27A zinc binding domain mutated | W303 | lanosterol | Details: altered sterol composition with accumulation of lanosterol | Villasmil ML, et al. (2020) PMID:32678853 |
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations.
8 entries for 2 genesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
This diagram displays Gene Ontology terms (green), phenotypes (blue), and macromolecular complexes (yellow) that are shared between the given chemical (black) and other chemicals (purple). The shared GO terms, phenotypes or complexes can be visualized separately using the radio button at the bottom of the graph.