Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
3 entries for 3 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| FKS1 | chemical compound accumulation: decreased | classical genetics | null Allele: fks1-E851A E851A; active site in the glycosyltransferase domain mutated; residue within the cellulose-synthase-like fold aligns well with bacteria cellulose synthase BcsA; results in decreased enzymatic activity | S288C | (1->3)-beta-D-glucan | Details: reduction in the levels of cell wall (1->3)-beta-D-glucan relative to wt | Hu X, et al. (2023) PMID:36949198 |
| FKS1 | growth in exponential phase: decreased rate | classical genetics | null Allele: fks1-E851A E851A; active site within the glycosyltransferase domain mutated; residue within the cellulose-synthase-like fold aligns well with bacteria cellulose synthase BcsA; reduced enzymatic activity | S288C | Details: slow growth rate relative to wt | Li J, et al. (2025) PMID:40021629 | |
| FKS1 | resistance to chemicals: decreased | classical genetics | null Allele: fks1-E851A E851A; active site in the glycosyltransferase domain mutated; residue within the cellulose-synthase-like fold aligns well with bacteria cellulose synthase BcsA; results in decreased enzymatic activity | S288C | 1 μg/ml tacrolimus (anhydrous) | Details: FK506 sensitive relative to wt | Hu X, et al. (2023) PMID:36949198 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
List of references used specifically to curate the information in Overview section.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | MetaboGeneCard | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap | YeastRC Two-Hybrid