Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
7 entries for 7 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| CAK1 | alkaline pH resistance: decreased | systematic mutation set | null Allele: cak1-Δ | S288C | 60 mM calcium dichloride | Media: alkaline conditions, pH 7.5 Media: YPD Details: growth defects at pH 7.5 in 60 mM calcium chloride - vma phenotype | Sambade M, et al. (2005) PMID:15937126 |
| CAK1 | chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | null Allele: cak1-Δ | S288C | Assay: diploid bimater (BiM) assay Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean | Choy JS, et al. (2013) PMID:23825022 | |
| CAK1 | inviable | systematic mutation set | null Allele: cak1-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| CAK1 | protein/peptide accumulation: decreased Reporter: SIC1 | homozygous diploid | null Allele: cak1-Δ | Other | Details: deficiency in degradation of Sic1p | Schindler K, et al. (2003) PMID:14612412 | |
| CAK1 | protein/peptide modification: decreased Reporter: Kin28-Myc | classical genetics | null Allele: cak1-Δ | W303 | Details: phosphorylation of Kin28 is essentially undetectable | Espinoza FH, et al. (1998) PMID:9774652 | |
| CAK1 | resistance to chemicals: decreased | heterozygous diploid, systematic mutation set mutants grown in 96-well microtiter plates | null Allele: cak1-Δ | S288C | 0.2 mg/ml sulfanilamide | Media: SMM liquid medium | Botet J, et al. (2007) PMID:17873082 |
| CAK1 | starvation resistance: decreased | heterozygous diploid, competitive growth measurement of fitness in a fluctuating environment, modeled using a semi-batch fermentor system | null Allele: cak1-Δ | S288C | Davey HM, et al. (2012) PMID:22356628 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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