Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
4 entries for 4 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| CCT2 | actin cytoskeleton morphology: abnormal | homozygous diploid | conditional Allele: cct2-1 | S288C | Temperature: reduced temperature, 14 °C Details: abnormally small cortical actin patches; actin cables less prominent; polarized distribution of actin cables and patches is lacking; accumulation of actin bars in ~50% of cells | Chen X, et al. (1994) PMID:7916460 | |
| CCT2 | cytoskeleton morphology: abnormal | homozygous diploid | conditional Allele: cct2-1 | S288C | Temperature: reduced temperature, 14 °C Details: severe microtubule assembly defect; ~50% of cells lack detectable microtubules, and half possess a single faint dot; <5% contain bipolar spindles | Chen X, et al. (1994) PMID:7916460 | |
| CCT2 | nuclear position: abnormal | classical genetics | conditional Allele: cct2-1 | S288C | Temperature: reduced temperature, 14 °C Details: ~10% of cells contain two nuclei in one cell body; >40% of large budded cells contain an undivided nucleus | Chen X, et al. (1994) PMID:7916460 | |
| CCT2 | spindle morphology: abnormal | homozygous diploid | conditional Allele: cct2-1 | S288C | Temperature: reduced temperature, 14 °C Details: <5% contain bipolar spindles; spindles in binucleate cells often fail to align through the bud neck | Chen X, et al. (1994) PMID:7916460 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
List of references used specifically to curate the information in Overview section.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap