Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
43 entries for 30 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| FUS3 | autophagy: decreased | classical genetics | null Allele: fus3-Δ | Other | Media: nitrogen starvation Details: autophagy assayed by delivery of cytoplasmic Pho8p to vacuole | Umekawa M and Klionsky DJ (2012) PMID:22447937 | |
| FUS3 | bud morphology: abnormal | systematic mutation set | null Allele: fus3-Δ | S288C | Details: bud is abnormally elongated | Watanabe M, et al. (2009) PMID:19466415 | |
| FUS3 | cell death: absent | classical genetics | null Allele: fus3-Δ | S288C | Treatment: human caspase-10 | Lisa-Santamaría P, et al. (2012) PMID:22782902 | |
| FUS3 | chemical compound accumulation: abnormal | systematic mutation set | null Allele: fus3-Δ | S288C | alpha-amino acid | Details: Significantly altered free amino acid profile (X^2- test p < 0.01) | Mülleder M, et al. (2016) PMID:27693354 |
| FUS3 | chemical compound accumulation: decreased | classical genetics | null Allele: fus3-Δ | S288C | calcium(2+) | Treatment: alpha-factor Details: decreased low-affinity Ca2+ influx | Muller EM, et al. (2003) PMID:12878605 |
| FUS3 | chemical compound accumulation: increased | homozygous diploid | null Allele: fus3-Δ | Sigma1278b | 1D-myo-inositol bis(diphosphate) tetrakisphosphate | Media: low nitrogen (SLAD) Details: elevated levels of InsP8 relative to wt under conditions of low nitrogen availability | Norman KL, et al. (2018) PMID:29939992 |
| FUS3 | chronological lifespan: decreased | systematic mutation set | null Allele: fus3-Δ | S288C | Campos SE, et al. (2018) PMID:29575540 | ||
| FUS3 | chronological lifespan: increased | classical genetics | null Allele: fus3-Δ | S288C | Media: SD + 0.5% glucose | Aluru M, et al. (2017) PMID:29273704 | |
| FUS3 | endocytosis: decreased | systematic mutation set | null Allele: fus3-Δ | S288C | Details: defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 | Burston HE, et al. (2009) PMID:19506040 | |
| FUS3 | endocytosis: decreased | classical genetics | null Allele: fus3-Δ | S288C | Details: defective internalization of a chimeric Snc1p reporter, GFP-Snc1-Suc2 reporter | Burston HE, et al. (2009) PMID:19506040 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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