Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
5 entries for 5 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| DHH1 | invasive growth: decreased | classical genetics | reduction of function Allele: dhh1-Δ79 79 amino acid deletion, C-terminal Q/P-rich region | Sigma1278b | Details: weak defects in haploid invasive growth | Lee E, et al. (2020) PMID:32989641 | |
| DHH1 | mating efficiency: decreased | classical genetics | reduction of function Allele: dhh1-Δ79 79 amino acid deletion, C-terminal Q/P-rich region | S288C | Details: mating efficiency reduced to 77% that of wt | Jung D, et al. (2017) PMID:28455591 | |
| DHH1 | protein/peptide accumulation: decreased Reporter: Ste12-HA | classical genetics | reduction of function Allele: dhh1-Δ79 79 amino acid deletion, C-terminal Q/P-rich region | S288C | Details: moderate reduction in the levels of Ste12p to ~ 52% that of wt cells | Jung D, et al. (2017) PMID:28455591 | |
| DHH1 | protein/peptide accumulation: increased Reporter: Ste12::HA | homozygous diploid | reduction of function Allele: dhh1-Δ79 79 amino acid deletion, C-terminal Q/P-rich region | Sigma1278b | Media: nitrogen starvation (SLAD) Details: slightly higher levels of Ste12p, a protein induced in wt cells under filamentation-inducing conditions | Lee E, et al. (2020) PMID:32989641 | |
| DHH1 | shmoo formation: decreased | classical genetics | reduction of function Allele: dhh1-Δ79 79 amino acid deletion, C-terminal Q/P-rich region | S288C | Details: severe defect with only 52% able to form shmoos relative to wt cells | Jung D, et al. (2017) PMID:28455591 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
List of references used specifically to curate the information in Overview section.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | MetaboGeneCard | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap | YeastRC Two-Hybrid