Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
20 entries for 12 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| THP3 | cell size: increased | systematic mutation set analysis of cell size for mutants in the systematic deletion collection | null Allele: thp3-Δ | S288C | Details: mutant is among the largest 5% of haploid deletion strains | Jorgensen P, et al. (2002) PMID:12089449 | |
| THP3 | chemical compound accumulation: abnormal | systematic mutation set | null Allele: thp3-Δ | S288C | alpha-amino acid | Details: Significantly altered free amino acid profile (X^2- test p < 0.01), showing 1 simultaneous amino acid change (Z-test, adjusted p < 0.01) | Mülleder M, et al. (2016) PMID:27693354 |
| THP3 | chemical compound accumulation: increased | systematic mutation set | null Allele: thp3-Δ | S288C | glutamate(1-) | Mülleder M, et al. (2016) PMID:27693354 | |
| THP3 | chronological lifespan: decreased | systematic mutation set | null Allele: thp3-Δ | S288C | Marek A and Korona R (2013) PMID:24151994 | ||
| THP3 | competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: thp3-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.764 | Breslow DK, et al. (2008) PMID:18622397 | |
| THP3 | competitive fitness: decreased | systematic mutation set | null Allele: thp3-Δ | S288C | Media: synthetic oak exudate medium, OAK | Qian W, et al. (2012) PMID:23103169 | |
| THP3 | endoplasmic reticulum morphology: abnormal | systematic mutation set | null Allele: thp3-Δ | S288C | Details: overexpanded ER; identified with an inducible ER biogenesis system using ino2*, a variant that cannot be inhibited by Opi1p, driving ER membrane biogenesis | Papagiannidis D, et al. (2021) PMID:34617598 | |
| THP3 | metal resistance: decreased | systematic mutation set | null Allele: thp3-Δ | S288C | lithium(1+) | Treatment: lithium chloride, 50 mM Details: null mutants with residual growth between 50-90% at 50 mM LiCl were classified as having medium sensitivity; screen consisted of a 4 step approach including qualitative assessment on Li-agar plates, liquid microplate assessment, tertiary screening in liquid and a quaternary screen using Li2SO4, followed by classification based on the degree of sensitivity | Fierling N, et al. (2024) PMID:38142127 |
| THP3 | resistance to chemicals: decreased | classical genetics | null Allele: thp3-Δ | S288C | 150 ug/ml mycophenolic acid | Jimeno S, et al. (2011) PMID:21149575 | |
| THP3 | resistance to chemicals: decreased | classical genetics | null Allele: thp3-Δ | S288C | 6-azauracil | Jimeno S, et al. (2011) PMID:21149575 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | MetaboGeneCard | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap