Gene Ontology Help

Nonsense-mediated decay complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Recognizes and elicits the rapid degradation of mRNAs that prematurely terminate translation and also regulates the expression of specific genes by degrading natural mRNAs. Nonsence-mediated decay (NMD) is triggered by the messenger ribonucleoprotein (mRNP) context surrounding the translation termination event. NMD targets can be recognized as targets due to the lack of factors bound downstream from the termination codon. A ribosome terminating translation at a termination codon substantially upstream from the poly(A) tail terminates translation inefficiently. NMD may occur because the PAB1 (P04147) or other factor bound to the poly(A) tail is not in close enough proximity to the terminating ribosome to enable interaction of the PAB1 with SUP35 (P05453), which is bound to the terminating ribosome and thus establishes the correct mRNP context for a normal translation termination event. In the absence of correct translation termination, the nonsense-mediated decay complex interacts with the translation release factor ERF1-ERF3 complex (CPX-435), resulting in an aberrant translation termination event and NMD activation. NMD activation leads to the decapping of the mRNA by the decapping complex, DCP1-DCP2 (CPX-1628), followed by 5-prime to 3-prime degradation of the mRNA by the exoribonuclease XRN1 (P22147).
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, helicase activity, ion binding, RNA catabolic process, catabolic process, nucleobase-containing compound catabolic process, cytoplasm