Gene Ontology Help

MON1-CCZ1 guanyl-nucleotide exchange factor complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Guanyl-nucleotide exchange factor complex required to activate the endosomal GTPase Rab7 required for fusion of multivesicular bodies/late endosomes and of autophagosomes to lysosomes. Maintains proper vacuole morphology in vacuole delivery pathways by regulating fusion of vesicles with the vacuole at the tethering/docking stage. Regulates the SNARE complex during the coordinated priming and docking stages of fusion. May play a role in early-to-late endosome conversion. Mon1 interacts with Rab5 family GTPases and phosphatidylinositol phosphate lipids to recruit the complex to endosomes. For binding to autophagosomes, Ccz1 instead interacts with ATG8 and lipid packing defects.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

endosomal transport, transport, vacuolar transport, vesicle-mediated transport