Gene Ontology Help

MRE11-RAD50-XRS2 meiotic recombination initiation complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Combined ATPase/endo/ 3-prime exonuclease complex which both senses and removes blocked DNA ends. The hydrolysis of ATP enables the complex to cleave DNA 15-25 base pairs away from diverse blocks through endonuclease activity. Plays a crucial role in mitotic cells for sensing and repairing double-stranded breaks (DSB) and is also required for meiotic recombination. Required for the formation of the DSB catalysed by the transesterase SPO11 (P23179) protein and subsequently removes covalently attached Spo11 from the 5' extremity of the breaks through its nuclease activity, to allow further break resection. The Mre11 complex also plays a role during meiosis in bridging DNA molecules together and in sensing SPO11 DSB and activating the DNA damage checkpoint. Clips double-stranded DNA in the vicinity of protein-blocked DNA ends.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, DNA binding, hydrolase activity, nuclease activity, DNA damage response, DNA metabolic process, DNA repair, chromosome organization, response to stress, nucleus, organelle