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RAD26-DEF1 stalled RNAPII response complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Appears to form in response to DNA damage-stalled RNA polymerase II (RNAPII, CPX-2662), when the stall is persistent such as at DNA lesions. RAD26 appears to protect RNAPII from degradation to allow time for repair. When the lesion cannot be rapidly removed by RAD26-promoted DNA repair, DEF1 enables ubiquitination and proteolysis of RNAPII. The complex may therefore act to coordinate a stalling rescue mechanism driven by the two proteins.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA damage response, response to stress