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General transcription factor TFIIF complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
General transcription factor that interacts with RNAPII and can recruit RNAPII to a preinitiation complex containing TFIID and TFIIB. Required for the opening of DNA, to allow transcription initiation. DNA opening occurs around the tip of the Pol II clamp and the TFIIE (CPX-1658) ‘extended winged helix’ domain. TFIIF and TFIIE bind open promoter DNA from opposite sides of the Pol II cleft. TFIIF adopts an extended induced structure that allows it to retain the upstream DNA–SPT15–TFIIB assembly on the wall and to bind the DNA bubble. TFIIF and TFIIE encircle and retain the DNA and TFIIE may then act to stabilize the open DNA structure.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, DNA-templated transcription initiation, biosynthetic process, cellular component assembly, protein-containing complex assembly, nucleus, organelle