Zhu Y, et al. (2025) Beyond CEN.PK - parallel engineering of selected S. cerevisiae strains reveals that superior chassis strains require different engineering approaches for limonene production. Metab Eng
PMID: 40334774
Maya-Miles D, et al. (2025) Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle. PLoS One 20(5):e0317650
PMID: 40333925
Danyo EK, et al. (2025) The impact of pre-radiation exposure on physiological and fermentation activity of <i>Saccharomyces cerevisiae</i> SAF Ale S-33. Int J Radiat Biol 1-9
PMID: 40333000
Capaci V, et al. (2025) Uncovering a Novel Pathogenic Mechanism of <i>BCS1L</i> in Mitochondrial Disorders: Insights from Functional Studies on the c.38A>G Variant. Int J Mol Sci 26(8)
PMID: 40332224
Zhang F, et al. (2025) The Yeast Gsk-3 Kinase Mck1 Is Necessary for Cell Wall Remodeling in Glucose-Starved and Cell Wall-Stressed Cells. Int J Mol Sci 26(8)
PMID: 40332024
Tarakhovskaya ER, et al. (2025) Vulnerable Nucleotide Pools and Genomic Instability in Yeast Strains with Deletion of the <i>ADE12</i> Gene Encoding for Adenylosuccinate Synthetase. Int J Mol Sci 26(8)
PMID: 40331943
Seong MJ, et al. (2025) Automated Construction of a Yeast-Based Multigene Library via Homologous Recombination in a Biofoundry Workflow. ACS Synth Biol
PMID: 40331904
Yang C, et al. (2025) Effects of Patulin Stress on the Physiology, Fermentation Performance, and Aroma Profile of Saccharomyces cerevisiae During Fermentation. J Food Sci 90(5):e70248
PMID: 40331780
Jeon G, et al. (2025) Impact of Culture Duration on the Properties and Functionality of Yeast-Derived Extracellular Vesicles. Biomater Res 29:0201
PMID: 40330275
Yerlikaya O, et al. (2025) Impact of Yeast Types on Quality Characteristics and Storage Stability of Industrial Kefir. Food Sci Nutr 13(5):e70238
PMID: 40330201
Chapman H, et al. (2025) Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models. Bioinformatics
PMID: 40327453
Liu X, et al. (2025) Rational Design and Model Predictions for Optimized Elastase Production in <i>Saccharomyces cerevisiae</i>. ACS Synth Biol
PMID: 40327375
Ptak C, et al. (2025) Ulp1 association with nuclear pore complexes is required for the maintenance of global SUMOylation. Mol Biol Cell mbcE24120563
PMID: 40327319
Kennedy T, et al. (2025) Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle. Mol Biol Cell mbcE25010009
PMID: 40327364
Koide H, et al. (2025) Solution AFM imaging and coarse-grained molecular modeling of yeast condensin structural variation coupled to the ATP hydrolysis cycle. J Mol Biol 169185
PMID: 40324744
Xia T, et al. (2025) Regulation of Arginine Metabolism and Ethanol Tolerance in <i>Saccharomyces cerevisiae</i> by <i>BTN2</i>. Food Sci Nutr 13(5):e70244
PMID: 40321608
Meister C, et al. (2025) Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae. DNA Repair (Amst) 149:103842
PMID: 40319547
Roy M, et al. (2025) EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA. Nat Commun 16(1):4141
PMID: 40319035
Chen RR, et al. (2025) Identification of key transcription factors, including DAL80 and CRZ1, involved in heat and ethanol tolerance in Saccharomyces cerevisiae. Biotechnol Biofuels Bioprod 18(1):50
PMID: 40319324
Tang Y, et al. (2025) The influencing mechanisms of different characteristics of polystyrene microplastics on <i>Saccharomyces cerevisiae</i>: functional group, particle size and dosage. Environ Technol 1-14
PMID: 40324336
Anh TTQ, et al. (2025) Characterization of Red Dragon Fruit Wine Fermented with a Newly Identified Yeast Strain <i>Saccharomyces cerevisiae</i> M7. Food Technol Biotechnol 63(1):4-13
PMID: 40322290
Engelberg D, et al. (2025) The Saccharomyces cerevisiae ∑1278b strain is sensitive to NaCl because of mutations in its ENA1 gene. FEMS Yeast Res
PMID: 40317084
Gupta A, et al. (2025) Accurate, scalable, and fully automated inference of species trees from raw genome assemblies using ROADIES. Proc Natl Acad Sci U S A 122(19):e2500553122
PMID: 40314967
Roumestand C, et al. (2025) Understanding the Relationship between Pressure and Temperature Unfolding of Proteins. JACS Au 5(4):1940-1955
PMID: 40313814
Zhang L, et al. (2025) VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex. Mol Biol Cell mbcE24110490
PMID: 40305106
Dai W, et al. (2025) PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1. Nat Commun 16(1):4030
PMID: 40301306
Bosch-Crespo DM, et al. (2025) Wine pH could affect the interaction between yeast mannoproteins and flavanolic compounds. J Sci Food Agric
PMID: 40312837
Denkiewicz-Kruk M, et al. (2025) Effects of CDC45 mutations on DNA replication and genome stability. Biochim Biophys Acta Mol Cell Res 1872(5):119936
PMID: 40139510
Fenech EJ, et al. (2025) Profiling the LAM Family of Contact Site Tethers Provides Insights into Their Regulation and Function. Contact (Thousand Oaks) 8:25152564251321770
PMID: 40291949
Faz-Cortez OA, et al. (2025) Computational analysis of polymorphic residues in maltose and maltotriose transporters of a wild <i>Saccharomyces cerevisiae</i> strain. Open Life Sci 20(1):20251080
PMID: 40291777
Dudziak A, et al. (2025) The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15. EMBO J
PMID: 40281358
Jiang T, et al. (2024) Amplified and distinctive genotoxicity of titanium dioxide nanoparticles in transformed yeast reporters with human cytochrome P450 (CYP) genes. J Hazard Mater 474: 134850.
PMID: 38850947
Sun Q, et al. (2025) Unraveling Time-Resolved Transcriptional and Metabolic Shifts in the Mixed Fermentation of <i><i>Saccharomyces cerevisiae</i></i> and <i>Hanseniaspora uvarum</i>. J Agric Food Chem
PMID: 40310988
Herring P, et al. (2025) A cellular system to study responses to a collision between the transcription complex and a protein-bound nick in the DNA template. FEBS Lett
PMID: 40309784
Andrews SS and Brent R (2025) Individual yeast cells signal at different levels but each with good precision. R Soc Open Sci 12(4):241025
PMID: 40309186
Dennler O and Ryan CJ (2025) Evaluating sequence and structural similarity metrics for predicting shared paralog functions. NAR Genom Bioinform 7(2):lqaf051
PMID: 40290317
Sonawala U, et al. (2025) Characterization and whole genome sequencing of Saccharomyces cerevisiae strains lacking several amino acid transporters: Tools for studying amino acid transport. PLoS One 20(4):e0315789
PMID: 40305508
Miloshev G, et al. (2025) Linker Histones Maintain Genome Stability and Drive the Process of Cellular Ageing. Front Biosci (Landmark Ed) 30(4):26823
PMID: 40302323
Wu Y, et al. (2025) Robust Saccharomyces cerevisiae by rational metabolic engineering for effective ethanol production from undetoxified steam-exploded corn stover hydrolysate. Bioresour Technol 132605
PMID: 40306336
Yang J, et al. (2025) De Novo Production of Piceatannol via Construction of Interconnected Biosynthetic Pathways in a Single <i>Saccharomyces cerevisiae</i> Strain. J Agric Food Chem
PMID: 40305414
Folger A, et al. (2025) Regulation of misfolded protein aggregation and degradation by SUMOylation in budding yeast. Mol Biol Cell mbcE24120540
PMID: 40305096
Mohanan G, et al. (2025) Genotoxic stress triggers Scd6-dependent regulation of translation to modulate the DNA damage response. EMBO Rep
PMID: 40275106
Mitra S and Hartemink AJ (2025) Inferring differential protein binding from time-series chromatin accessibility data. Bioinform Adv 5(1):vbaf080
PMID: 40297777
Minami A, et al. (2025) The ribonuclease RNase T2 mediates selective autophagy of ribosomes induced by starvation in Saccharomyces cerevisiae. J Biol Chem 108554
PMID: 40294649
Almyre C, et al. (2025) The copper ionophore disulfiram improves mitochondrial function in various yeast and human cellular models of mitochondrial diseases. Hum Mol Genet
PMID: 40298238
Su C, et al. (2025) Comparative adaptability of 307 <i>Saccharomyces cerevisiae</i> strains from winemaking and Mantou fermentation. Front Microbiol 16:1581370
PMID: 40291801
Chen M, et al. (2025) Allosteric Effectors Outcompete Transcript Levels and Substrate Concentration in Regulating Central Carbon Flux During the Crabtree Effect Transition. Biotechnol J 20(4):e70024
PMID: 40289311
Neto VG, et al. (2025) New Insights into nuclear import and nucleolar localization of yeast RNA exosome subunits. Mol Biol Cell mbcE25020078
PMID: 40266794
Kwun MS and Lee DG (2025) Ferroptosis-Like Death Induction in <i>Saccharomyces cerevisiae</i> by Gold Nanoparticles. J Microbiol Biotechnol 35:e2501029
PMID: 40295204
Chen Z, et al. (2025) A systematic study of regulating inorganic polyphosphates production in <i>Saccharomyces cerevisiae</i>. Synth Syst Biotechnol 10(3):816-826
PMID: 40291979
Ruden DM (2025) GC Content in Nuclear-Encoded Genes and Effective Number of Codons (ENC) Are Positively Correlated in AT-Rich Species and Negatively Correlated in GC-Rich Species. Genes (Basel) 16(4)
PMID: 40282392
Mori K, et al. (2025) Comparative metabolome analysis of sake yeast with enhanced fermentation performance in sake fermentation conditions. J Biosci Bioeng
PMID: 40288942
Dubey P, et al. (2025) Seo1p, a high affinity, plasma membrane transporter of the γ-Glu-met dipeptide in yeasts and fungi. J Biol Chem 108539
PMID: 40288644
Chen X, et al. (2025) The effects of carbendazim on metabolic pathways of Saccharomyces cerevisiae Saflager S-189 and beer characteristics. Int J Food Microbiol 437:111219
PMID: 40288109
Wei Y, et al. (2025) Impact of Co-Inoculation Patterns of <i>Wickerhamomyces anomalus</i> and <i>Saccharomyces cerevisiae</i> on Cider Quality and Aromatic Profiles. Molecules 30(7)
PMID: 40286241
Muñoz-Castells R, et al. (2025) Application of an Electronic Nose to the Prediction of Odorant Series in Wines Obtained with <i>Saccharomyces</i> or Non-<i>Saccharomyces</i> Yeast Strains. Molecules 30(7)
PMID: 40286168
Li Y, et al. (2025) Molecular Mechanisms of Pathogenic Fungal Virulence Regulation by Cell Membrane Phospholipids. J Fungi (Basel) 11(4)
PMID: 40278077
Han B, et al. (2025) Definer: A computational method for accurate identification of RNA pseudouridine sites based on deep learning. PLoS One 20(4):e0320077
PMID: 40273178
Zhang T, et al. (2025) Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae. FEBS J
PMID: 40272088
Ludwig K and Heidorn-Czarna M (2025) Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast. Plant Cell Physiol
PMID: 40269524
Niphadkar S, et al. (2025) Protocol to quantitatively assess glycolysis and related carbon metabolic fluxes using stable isotope tracing in Crabtree-positive yeasts. STAR Protoc 6(2):103786
PMID: 40266845
Matsuzaki M, et al. (2025) TRS85 and LEM3 suppressor mutations rescue stress hypersensitivities caused by lack of structural diversity of complex sphingolipids in budding yeast. FEBS J
PMID: 40266832
Martins C, et al. (2025) Whole yeast cell synthesis of 5-hydroxymethylfurfural-derivatives from apple waste processed by green technologies. Bioresour Technol 430:132570
PMID: 40268096
Juarez-Contreras I, et al. (2025) Structural dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation. Sci Adv 11(17):eadu7190
PMID: 40267201
Li Y, et al. (2025) Coarse-Grained Modeling Elucidates Differential Metabolism of <i>Saccharomyces cerevisiae</i> under Varied Nutrient Limitations. ACS Synth Biol
PMID: 40266044
Chen Q, et al. (2025) Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids. Nat Commun 16(1):3740
PMID: 40258825
Fujiwara H, et al. (2025) <sup>13</sup>C-metabolic flux analysis of <i>Saccharomyces cerevisiae</i> in complex media. Metab Eng Commun 20:e00260
PMID: 40256657
Zeng L, et al. (2025) Checkpoint and recombination pathways independently suppress rates of spontaneous homology-directed chromosomal translocations in budding yeast. Front Genet 16:1479307
PMID: 40255487
Minebois R, et al. (2025) Combined Isotopic Tracer and Modelling Approach Reveals Differences in Nitrogen Metabolism in S. cerevisiae, S. uvarum and S. kudriavzevii Species. Microb Biotechnol 18(4):e70087
PMID: 40251794
Podh NK, et al. (2025) Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in <i>Saccharomyces cerevisiae</i>. Life Sci Alliance 8(7)
PMID: 40250989
Lee MK, et al. (2025) Nutrient starvation-induced Hda1C rewiring: coordinated regulation of transcription and translation. Nucleic Acids Res 53(7)
PMID: 40248913
Trubitsina NP, et al. (2025) Prion-Dependent Lethality of <i>sup35</i> Missense Mutations Is Caused by Low GTPase Activity of the Mutant eRF3 Protein. Int J Mol Sci 26(7)
PMID: 40244414
Ma M, et al. (2025) Overexpression of tRNA m<sup>7</sup>G modification methyltransferase complex promotes the biosynthesis of triterpene in yeast. Front Microbiol 16:1557443
PMID: 40231236
Pan Y, et al. (2025) Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II. Nat Struct Mol Biol 32(4):687-697
PMID: 39779918
Ghogare SS and Pathan EK (2025) Intratumor fungi specific mechanisms to influence cell death pathways and trigger tumor cell apoptosis. Cell Death Discov 11(1):188
PMID: 40258837
Muguet A, et al. (2025) Psoralen Crosslinking-Chromatin Endogenous Cleavage Assay to Examine Histone DNA Interactions of Active and Inactive rRNA Genes. Methods Mol Biol 2919:133-154
PMID: 40257561
Sterrett MC, et al. (2025) Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation. RNA
PMID: 40246537
Liu Y, et al. (2025) RNA Modifications and Prp24 Coordinate Lsm2-8 Binding Dynamics during S. cerevisiae U6 snRNP Assembly. J Biol Chem 108497
PMID: 40216252
Collins BM and Cullen PJ (2025) Separation of powers: A key feature underlying the neuroprotective role of Retromer in age-related neurodegenerative disease? Curr Opin Cell Biol 94:102516
PMID: 40253888
Tu S, et al. (2025) Enhanced chlorogenic acid production from glucose via systematic metabolic engineering of <i>Saccharomyces cerevisiae</i>. Synth Syst Biotechnol 10(3):707-718
PMID: 40248482
Yone H, et al. (2025) Light-controlled Spo11-less meiotic DNA breaks by MagTAQing lead to chromosomal aberrations. Nucleic Acids Res 53(7)
PMID: 40207630
Singh G, et al. (2025) Active control of mitochondrial network morphology by metabolism-driven redox state. Proc Natl Acad Sci U S A 122(16):e2421953122
PMID: 40244668
Tominaga M, et al. (2025) Production of borneol, camphor, and bornyl acetate using engineered <i>Saccharomyces cerevisiae</i>. Metab Eng Commun 20:e00259
PMID: 40242661
Gogianu LI, et al. (2025) KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca<sup>2+</sup>-mediated response to dimethylsulfoxide (DMSO). FEBS Open Bio
PMID: 40214101
Li Q, et al. (2025) Transcriptome profiling unravels improved ethanol production and acetic acid tolerance in yeast by preculture of wheat gluten hydrolysates. J Biotechnol 403:103-114
PMID: 40246175
Wang Q, et al. (2025) Highly Efficient Display of Oligomeric Enzymes on Yeast Surface for Enhanced Glycyrrhizin Hydrolysis and Cellulosic Ethanol Production. ACS Synth Biol
PMID: 40230192
Xiao T and Ünal E (2025) Remodeling, compartmentalization, and degradation: a trifecta for organelle quality control during gametogenesis. Curr Opin Genet Dev 92:102347
PMID: 40233504
Liu S, et al. (2025) Yeast models of mutations in NFU1 gene for biochemical characterization and drug screening. Biochem Biophys Res Commun 763:151760
PMID: 40233434
Fiorentino F, et al. (2025) Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits. Nucleic Acids Res 53(7)
PMID: 40207627
Sanders J, et al. (2025) An Improved Cytological Assay for R-loop Detection in Saccharomyces cerevisiae Utilizing a Catalytically Inactive RNase H. G3 (Bethesda)
PMID: 40205716
Paternoga H, et al. (2025) Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit. Proc Natl Acad Sci U S A 122(15):e2415807122
PMID: 40198700
Kanai M, et al. (2025) Efficient genes identification via quantitative trait loci analysis by crossbreeding of sake and laboratory yeast. Appl Microbiol Biotechnol 109(1):84
PMID: 40198396
Singh R and Tomar RS (2025) An Uncharacterized Domain Within the N-Terminal Tail of Histone H3 Regulates the Transcription of FLO1 via Cyc8. Mol Microbiol
PMID: 40196922
Tran PHN and Lee TS (2025) Harnessing organelle engineering to facilitate biofuels and biochemicals production in yeast. J Microbiol 63(3):e2501006
PMID: 40195834
Chen X and Jin H (2025) Essential Roles of Conserved Pseudouridines in Helix 69 for Ribosome Dynamics in Translation. J Mol Biol 437(14):169132
PMID: 40194619
Horie F, et al. (2025) Yeast Hsp78 plays an essential role in adapting to severe ethanol stress via mild ethanol stress pretreatment in mitochondrial protein quality control. Biochim Biophys Acta Gen Subj 1869(6):130804
PMID: 40187374
Ungermann C and Moeller A (2025) Structuring of the endolysosomal system by HOPS and CORVET tethering complexes. Curr Opin Cell Biol 94:102504
PMID: 40187049
Deng R, et al. (2025) Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer. Cell Death Dis 16(1):254
PMID: 40185704
Greenwald E, et al. (2025) DragonRNA: Generality of DNA-primed RNA-extension activities by DNA-directed RNA polymerases. Nucleic Acids Res 53(6)
PMID: 40197829
Nelson CR, et al. (2025) Spindle integrity is regulated by a phospho-dependent interaction between the Ndc80 and Dam1 kinetochore complexes. PLoS Genet 21(4):e1011645
PMID: 40184422
Yu H, et al. (2025) Metabolic engineering of yeast to efficiently synthesize heme and hemoproteins: recent advance and prospects. FEMS Yeast Res 25
PMID: 40228812
Bengs BD, et al. (2025) Integrative approaches for predicting protein network perturbations through machine learning and structural characterization. J Proteomics 316:105439
PMID: 40228603
(2025) Correction for Sahi and Craig, Network of general and specialty J protein chaperones of the yeast cytosol. Proc Natl Acad Sci U S A 122(16):e2504093122
PMID: 40215286
Lam WH, et al. (2025) DNA bending mediated by ORC is essential for replication licensing in budding yeast. Proc Natl Acad Sci U S A 122(14):e2502277122
PMID: 40184174
Avellaneda Penatti NM, et al. (2025) Decreased levels of Prx1 are associated with proteasome impairment and mitochondrial dysfunction in the yeast Saccharomycescerevisiae. Arch Biochem Biophys 768:110406
PMID: 40180294
Baskin A, et al. (2025) All intrinsically active Erk1/2 mutants autophosphorylate Threonine207/188, a plausible regulator of the TEY motif phosphorylation. J Biol Chem 108509
PMID: 40222547
Kikuta H, et al. (2025) Genome-wide screening reveals repression by nuclear exosome as a prerequisite for intron-mediated enhancement in Saccharomyces cerevisiae. Biochim Biophys Acta Gene Regul Mech 1868(2):195089
PMID: 40220860
Cheng C, et al. (2025) Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in <i>Saccharomyces cerevisiae</i>. Sci Adv 11(15):eadv4082
PMID: 40215312
Patel M, et al. (2025) Expression, Purification, and Preliminary Characterization of Putative Protein Tyrosine Phosphatase Oca1. Protein Pept Lett
PMID: 40212001
Paukštytė J, et al. (2025) A dual reporter system for intracellular and extracellular amino acid sensing in budding yeast. Mol Biol Cell mbcE24040162
PMID: 40172974
Takaine M, et al. (2025) Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeast. PLoS Biol 23(4):e3003111
PMID: 40208903
Dhillon PK, et al. (2025) Harnessing killer yeast system: from molecular insight to real world biocontrol solution. Arch Microbiol 207(5):116
PMID: 40198331
Wei Y, et al. (2025) Integrated transcriptome and proteome analysis unveils black tea polyphenols metabolic pathways in Saccharomyces cerevisiae. Food Microbiol 130:104777
PMID: 40210400
Su WH, et al. (2025) Spermidine toxicity in Saccharomyces cerevisiae due to mitochondrial complex III deficiency. Biogerontology 26(2):91
PMID: 40208436
Simmons S, et al. (2025) A Saccharomyces cerevisiae knockout screen for genes critical for growth under sulfur- and nitrogen-limited conditions reveals intracellular sorting via vesicular transport systems. G3 (Bethesda)
PMID: 40205732
da Mata AMOF, et al. (2025) Protective effects of ascorbic acid against anticancer drug-induced oxidative stress and genotoxic damage in <i>Saccharomyces cerevisiae</i>. 3 Biotech 15(5):118
PMID: 40206055
Guo B, et al. (2025) Adaptively Evolved and Multiplexed Engineered <i>Saccharomyces cerevisiae</i> for Neutralizer-Free Production of l-Lactic Acid. J Agric Food Chem 73(15):9009-9018
PMID: 40191959
Moyo NP, et al. (2025) Recovery of Sustainable Yeast Proteins: A Mechanistic Study of Autolysis and Enzyme Proteolysis as Pretreatments for Mechanical Cell Rupture. J Agric Food Chem 73(15):9197-9209
PMID: 40190058
Amiama-Roig A, et al. (2025) A Rfa1-MN-based system reveals new factors involved in the rescue of broken replication forks. PLoS Genet 21(4):e1011405
PMID: 40168399
Ficarro SB, et al. (2025) Leveraging HILIC/ERLIC separations for online nanoscale LC-MS/MS analysis of phosphopeptide isoforms from RNA polymerase II C-terminal domain. J Chromatogr B Analyt Technol Biomed Life Sci 1257:124560
PMID: 40158465
Gupta N, et al. (2025) Distinct uS11/Rps14 interactions with the translation preinitiation complex differentially alter the accuracy of start codon recognition. Nucleic Acids Res 53(6)
PMID: 40156863