HRR25 / YPL204W Overview

Standard Name
HRR25 1
Systematic Name
KTI14 12 13
Feature Type
ORF , Verified
Conserved casein kinase, monopolin subunit; regulates diverse events including vesicular traffic, DNA repair, CVT pathway, cohesion cleavage, attachment of sister kinetochores at meiosis I, exit from meiosis II, and ribosomal subunit biogenesis; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p; homolog of mammalian CK1delta 2 3 4 5 6 7 8 9 10 11
Name Description
HO and Radiation Repair 1
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
5798 +/- 1727
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all HRR25 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Dual-specificity serine/threonine and tyrosine protein kinase that regulates various cellular processes including clathrin-mediated endocytosis, ER to Golgi vesicle-mediated transport, pexophagy, ribosome maturation, and the attachment of microtubules to kinetochores; subunit of monopolin complex; also localizes to different sites within the cell, including bud necks and tips, plasma membrane, Golgi, and spindle pole bodies

View computational annotations

Molecular Function

Manually Curated

Cellular Component

Manually Curated


Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Essential gene in S288C, non-essential in W303 and some other strain backgrounds; reduction-of-function mutations cause slow growth, abnormal cellular morphology, sensitivity to heat, X rays, killer toxins, caffeine, Calcofluor White and MMS, and increased production and excretion of inositol (Opi-); diploids are unable to sporulate
Disease Details


Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.

Yeast HRR25 is homologous to human CSNK1A1, CSNK1D, and CASK, and has been used to study familial adenomatous polyposis, cancer, brain diseases, neurodegenerative diseases, Alzheimer's disease, familial advanced sleep phase syndrome, and syndromic X-linked intellectual disability Najm type
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

875 total interactions for 630 unique genes

Physical Interactions

  • Affinity Capture-MS: 272
  • Affinity Capture-RNA: 9
  • Affinity Capture-Western: 38
  • Biochemical Activity: 44
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-purification: 2
  • PCA: 1
  • Reconstituted Complex: 46
  • Two-hybrid: 8

Genetic Interactions

  • Dosage Growth Defect: 2
  • Dosage Lethality: 3
  • Dosage Rescue: 2
  • Negative Genetic: 382
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 10
  • Positive Genetic: 39
  • Synthetic Growth Defect: 6
  • Synthetic Rescue: 7
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.