TAT2 / YOL020W Overview

Standard Name
TAT2 1
Systematic Name
LTG3 , SAB2 , SCM2 , TAP2 3 , HPG2 5
Feature Type
ORF , Verified
High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance 1 2 3 4
Name Description
Tryptophan Amino acid Transporter 1
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

TAT2 is located on the left arm of chromosome XV between DIS3 exosome core complex catalytic subunit and tRNA-Tyr; coding sequence is 1779 nucleotides long with 19 SNPs, 6 of which lead to amino acid polymorphisms
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Tat2p is 592 amino acids long, short-lived, low in abundance; ubiquitinylated on 7 lysines, phosphorylated on 2 serines
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
4315 +/- 2064
Half-life (hr)


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results. Click "YeastMine" to view all alleles in YeastMine.

View all TAT2 alleles in SGD search | YeastMine

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Aromatic amino acid transmembrane transporter involved in tryptophan transport; localizes to eisosome, plasma membrane and ER

View computational annotations

Biological Process

Manually Curated

Cellular Component

Manually Curated
Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant has increased replicative lifespan, increased telomere length, decreased accumulation of tryptophan, decreased competitive fitness, increased sensitivity to canavanine, increased resistance to cadmium and to azoles; heterozygous null is haploproficient; overexpression slows growth, increases cold sensitivity
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

Tat2p interacts physically with proteins involved in RNA catabolism; TAT2 interacts genetically with genes involved in transcription

132 total interactions for 106 unique genes

Physical Interactions

  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 8
  • Co-fractionation: 1
  • Co-localization: 2
  • PCA: 5
  • Two-hybrid: 2

Genetic Interactions

  • Dosage Growth Defect: 3
  • Dosage Lethality: 4
  • Dosage Rescue: 13
  • Negative Genetic: 64
  • Phenotypic Suppression: 6
  • Positive Genetic: 17
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 2
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

TAT2 transcription is upregulated by Cyc8p, Stp1p, and Tup1p; Tat2p protein stability is downregulated by Npr1p during response to rapamycin; Tat2p protein stability is downregulated by Rsp5p-Bul1p ubiquitin ligase complex during responses to tryptophan, phenylalanine, and tryrosine
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.