VMA4 / YOR332W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VMA4/YOL332W is a non-essential gene; null mutants are viable, slow-growing, and exhibit a range of phenotypic abnormalities. These mutants show decreased resistance to both acidic and alkaline pH levels, indicating impaired ability to survive in extreme pH environments. Anaerobic growth is decreased, suggesting difficulties in energy production under oxygen-limited conditions. The duration of cell cycle progression in the G1 phase is increased, which may affect cell division and growth rates. Competitive fitness is diminished, making these mutants less viable in when resources are scarce. Desiccation resistance is decreased, making them more vulnerable to dry conditions, and freeze-thaw resistance is also decreased, indicating heightened sensitivity to temperature fluctuations. Heat sensitivity is decreased, while innate thermotolerance is increased, suggesting a complex response to temperature stress. The morphology of lipid particles and mitochondria is abnormal, which may impact cellular metabolism and energy production. Metal resistance is decreased, and sporulation efficiency is reduced, affecting reproductive success. Toxin resistance is decreased, and vacuolar morphology is abnormal, which could affect cellular storage and organization.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources